A new microscope system that can take 3-D pictures of an embryonic mouse organ over 24 to 48 hours has shown Duke Medical Center researchers the first glimpse of the formation of blood vessels during development.
Among other things, a team lead by cell biologist Blanche Capel, Ph.D., has found a previously unknown mechanism in the formation of blood vessels that may help scientists better understand how a tumor rallies a blood supply to its aid. Read the rest of this entry »
A new study by Duke University researchers provides more evidence that the nitric oxide (NO) system in the life of a cell plays a key role in disease, and the findings point to ways to improve treatment of illnesses such as heart disease and cancer.
The nitric oxide system in cells is “a major biological signaling pathway that has been missed with regard to the way it controls proteins,” and it is linked to cancer and other diseases when the system goes awry, said Jonathan Stamler, M.D., a professor of medicine and biochemistry at Duke University Medical Center who worked on the study. Read the rest of this entry »
Researchers at Duke University Medical Center have uncovered definitive evidence that a small but potent subset of immune system B cells is able to regulate inflammation.
Using a new set of scientific tools to identify and count these cells, the team showed that these B cells can block contact hypersensitivity, the type of skin reactions that many people have when they brush against poison ivy. Read the rest of this entry »
Building faultless objects from faulty components may seem like alchemy. Yet scientists from the Weizmann Institute’s Computer Science and Applied Mathematics, and Biological Chemistry Departments have achieved just that, using a mathematical concept called recursion. ‘We all use recursion, intuitively, to compose and comprehend sentences like ‘the dog that chases the cat that bit the mouse that ate the cheese that the man dropped is black,’’ says Prof. Ehud Shapiro. Read the rest of this entry »
Using a breakthrough technology, researchers led by a Weill Cornell Medical College scientist have pinpointed the hormone estrogen as a key player in about half of all prostate cancers.
Estrogen-linked signaling helps drive a discrete and aggressive form of the disease caused by a chromosomal translocation, which in turn results in the fusion of two genes. Read the rest of this entry »
Once heralded as a promising obesity treatment, the hormone leptin lost its fat-fighting luster when scientists discovered overweight patients were resistant to its effects. But pairing leptin with just a minor amount of exercise seems to revive the hormone’s ability to fight fat again, University of Florida researchers recently discovered.
Chemicals found in green tea may be able to stave off the cognitive deficits that occur with obstructive sleep apnea (OSA), according to a new study published in the second issue for May of the American Thoracic Society’s American Journal of Respiratory and Critical Care Medicine. Read the rest of this entry »
Our ability to remember the objects, places and people within our environment is essential for everyday life, although the importance of this is only fully appreciated when recognition memory beings to fail, as in Alzheimer’s disease.
By blocking certain mechanisms that control the way that nerve cells in the brain communicate, scientists from the University of Bristol have been able to prevent visual recognition memory in rats.
A single neuron (centre) in the perirhinal cortex which is involved in memory processes. (Credit: Photo by Andy Doherty) Read the rest of this entry »
One of the more intriguing workhorses of the cell, a protein conglomerate called telomerase, has in its short history been implicated in some critical areas of medicine including cancer, aging and keeping stem cells healthy. With such a resume, telomerase has been the subject of avid interest by basic scientists and pharmaceutical companies alike, so you’d think at the very least people would know what it is.
Chemists from UCLA and the University of Washington have succeeded in creating “designer enzymes,” a major milestone in computational chemistry and protein engineering.
Designer enzymes will have applications for defense against biological warfare, by deactivating pathogenic biological agents, and for creating more effective medications.
The world’s best known writer of science fiction, Sir Arthur C Clarke was the first to propose satellite communications in 1945. One of his short stories inspired the World Wide Web, while another was later expanded to make the movie 2001: A Space Odyssey, which he co-wrote with director Stanley Kubrick. He has lived in Sri Lanka since 1956. This is the final video of a remarkable man of optimism and vision for us to cherish forever:
In an exclusive preview of his new book, The Stuff of Thought, Steven Pinker looks at language, and the way it expresses the workings of our minds. By analyzing common sentences and words, he shows us how, in what we say and how we say it, we’re communicating much more than we realize
Five consecutive years of flat funding the budget of the National Institutes of Health (NIH) is deterring promising young researchers and threatening the future of Americans’ health, a group of seven preeminent academic research institutions warned today. In a new report released here, the group of concerned institutions (six research universities and a major teaching hospital) described the toll that cumulative stagnant NIH funding is taking on the American medical research enterprise. And the leading institutions warned that if NIH does not get consistent and robust support in the future, the nation will lose a generation of young investigators to other careers and other countries and, with them, a generation of promising research that could cure disease for millions for whom no cure currently exists.
The machinery responsible for energy production in fat cells is working poorly as a result of obesity. Finnish research done at the University of Helsinki and the National Public Health Institute shows that this may aggravate and work to maintain the obese state in humans.
Scientists at the University of Washington and other institutions have identified 25 genes regulating lifespan in two organisms separated by about 1.5 billion years in evolutionary change. At least 15 of those genes have very similar versions in humans, suggesting that scientists may be able to target those genes to help slow down the aging process and treat age-related conditions.
Can we create new life out of our digital universe?” asks Craig Venter. And his answer is, yes, and pretty soon. He walks the TED2008 audience through his latest research into “fourth-generation fuels” — biologically created fuels with CO2 as their feedstock. His talk covers the details of creating brand-new chromosomes using digital technology, the reasons why we would want to do this, and the bioethics of synthetic life. A fascinating Q&A with TED’s Chris Anderson follows .
Neuroscientists studying the mind’s ability to process images have completed the first empirical study to demonstrate, using animal models, how populations of nerve cells in visual cortex adapt to changing images. Their findings could lead to sight-improving therapies for people following trauma or stroke. The study at The University of Texas Health Science Center at Houston appears in the March 13 issue of the journal Nature.
A compound found in soybeans almost completely prevented the spread of human prostate cancer in mice, according to a study published in the March 15 issue of Cancer Research, a journal of the American Association for Cancer Research.
Researchers say that the amount of the chemical, an antioxidant known as genistein, used in the experiments was no higher than what a human would eat in a soybean-rich diet.
One way of combating atherosclerosis is to reduce levels of “bad cholesterol” in the blood. Scientists at the Swedish medical university Karolinska Institutet have now identified the genes that bring about this beneficial effect.
Success in the laboratory suggests that a new compound can point the way to preventing active tuberculosis in people infected with the latent form of the bacterium, says a team led by researchers at Weill Cornell Medical College in New York City. A drug with such properties could also be useful in treating people who already have tuberculosis by shortening the lengthy treatment period. The discovery also points to new ways of thinking about fighting bacterial infection, which is becoming increasingly resistant to traditional antibiotics.
To reduce the severity of his seizures, Joe had the bridge between his left and right cerebral hemisphers (the corpus callosum) severed. As a result, his left and right brains no longer communicate through that pathway. This is an extraordinary insight into the machinary of the mind. Here’s what happens as a result:
All the crucial proteins in our bodies must fold into complex shapes to do their jobs. These snarled molecules grip other molecules to move them around, to speed up important chemical reactions or to grab onto our genes, turning them “on” and “off” to affect which proteins our cells make. Read the rest of this entry »
In a novel experiment, a USC biomedical engineer examines the intricate circuitry between hand manipulation skills and specialized neural circuits in the brain
Quickly moving your fingertips to tap or press a surface is essential for everyday life to, say, pick up small objects, use a BlackBerry or an iPhone. But researchers at the University of Southern California say that this seemingly trivial action is the result of a complex neuro-motor-mechanical process orchestrated with precision timing by the brain, nervous system and muscles of the hand
The GelSpray Liquid Bandage is a major advance in the management and care of combat casualty and civilian wounds. Much like epoxy is dispensed in household kits, the dressing is applied with a dual syringe that releases two polymer ingredients. These polymers react rapidly upon mixing to form a gel-based dressing that frontline combat soldiers can apply to their own wounds. The dressing conforms to the wound geometry, adheres to intact skin but not directly to the injured tissue, and resists abrasion.n.Read the rest of this entry »
The Nucleic Acid Programmable Protein Array (NAPPA) was developed at the Harvard Institute of Proteomics and led to the spin-out of Auguron about a year ago. The firm says this technology enables proteins from any gene in the genome to be generated on microchips from surface printed DNA. Read the rest of this entry »
University of Oregon scientists say they have identified a gene that is the key switch that allows embryonic cells to form into muscles in zebrafish.Read the rest of this entry »
Why do some people solve problems more creatively than others? Are people who think creatively somehow different from those who tend to think in a more methodical fashion?
These questions are part of a long-standing debate, with some researchers arguing that what we call “creative thought” and “noncreative thought” are not basically different. If this is the case, then people who are thought of as creative do not really think in a fundamentally different way from those who are thought of as noncreative. On the other side of this debate, some researchers have argued that creative thought is fundamentally different from other forms of thought. If this is true, then those who tend to think creatively really are somehow different. Read the rest of this entry »
Researchers at the Picower Institute for Learning and Memory at MIT report in the Jan. 24 online edition of Science that they have created a way to see, for the first time, the effect of blocking and unblocking a single neural circuit in a living animal.
This revolutionary method allowed Susumu Tonegawa, Picower Professor of Biology and Neuroscience, and colleagues to see how bypassing a major memory-forming circuit in the brain affected learning and memory in mice.
Genes have the ability to recognise similarities in each other from a distance, without any proteins or other biological molecules aiding the process, according to new research. This discovery could explain how similar genes find each other and group together in order to perform key processes involved in the evolution of species. Read the rest of this entry »
Bacteria have evolved complex mechanisms called quorum sensing systems that provide for cell-to-cell communication, an adaptation that allows them to wait until their population grows large enough before mounting an attack on a host or competing for nutrients. Lianhong Sun, a chemical engineer at the University of Massachusetts Amherst, has engineered one of these systems to create genetic switches that could lower the cost of producing therapeutic proteins and pharmaceuticals. Read the rest of this entry »
What if swallowing a pill with a camera could detect the earliest signs of cancer? The tiny camera is designed to take high-quality, color pictures in confined spaces. Such a device could find warning signs of esophageal cancer, the fastest growing cancer in the United States.
A fundamentally new design has created a smaller endoscope that is more comfortable for the patient and cheaper to use than current technology. Its first use on a human, scanning for early signs of esophageal cancer, will be reported in an upcoming issue of IEEE Transactions on Biomedical Engineering. Read the rest of this entry »
By now, everyone knows that overweight people have a higher risk of heart attacks, strokes and other problems that arise from clogged, hardened arteries. And people who carry their extra weight around their waist – giving them a “beer belly” or an “apple” shape — have the highest risk of all.But despite the impact on human health, the reasons behind this connection between heart disease and belly fat – also known as visceral fat — have eluded scientists. Now, a new study in mice gives the first direct evidence of why this link might exist – and a tantalizing look at how it might be broken. Read the rest of this entry »
I have been following JoVE is the Journal of Visualized Experiments, for some time. This very unique “video journal” focuses on publishing videos of experimental procedures in life sciences.
Today I learned JoVE may soon be indexed on Pubmed, which will give it a credibility of peer reviewed scientific journal. Apparently they have also signed agreement with established science publishing companies (Annual Reviews, Springer Protocols, Current Protocols) for joint protocol publication, as in this example.. I think this is extremely useful for scientists or those who want to see actual experiments done. It will be interesting to see how it develops and accepted in scientific community.
Just as many scientists had given up the search, researchers have discovered that the pancreas does indeed harbor stem cells with the capacity to generate new insulin-producing beta cells. If the finding made in adult mice holds for humans, the newfound progenitor cells will represent an obvious target for therapeutic regeneration of beta cells in diabetes, the researchers report in the Jan. 25 issue of Cell, a publication of Cell Press. Read the rest of this entry »
Like fine china and crystal, which tend to be used sparingly, stem cells divide infrequently. It was thought they did so to protect themselves from unnecessary wear and tear. But now new research from Rockefeller University has unveiled the protein that puts the brakes on stem cell division and shows that stem cells may not need such guarded protection to maintain their potency. Read the rest of this entry »
A team of 17 researchers at the J. Craig Venter Institute (JCVI) has created the largest man-made DNA structure by synthesizing and assembling the 582,970 base pair genome of a bacterium, Mycoplasma genitalium JCVI-1.0. This work, published online today in the journal Science by Dan Gibson, Ph.D., et al, is the second of three key steps toward the team’s goal of creating a fully synthetic organism. In the next step, which is ongoing at the JCVI, the team will attempt to create a living bacterial cell based entirely on the synthetically made genome. Read the rest of this entry »
Using embryonic stem cells from mice, UT Southwestern Medical Center researchers have prompted the growth of healthy – and more importantly, functioning – muscle cells in mice afflicted with a human model of Duchenne muscular dystrophy.
The study represents the first time transplanted embryonic stem cells have been shown to restore function to defective muscles in a model of muscular dystrophy. Read the rest of this entry »
It’s good news that we are living longer, but bad news that the longer we live, the better our odds of developing late-onset Alzheimer’s disease.
Many Alzheimer’s researchers have long touted fish oil, by pill or diet, as an accessible and inexpensive “weapon” that may delay or prevent this debilitating disease. Now, UCLA scientists have confirmed that fish oil is indeed a deterrent against Alzheimer’s, and they have identified the reasons why.
Nature knows how to make proteins and nucleic acids (DNA and RNA) dance to assemble and sustain life. Inspired by this proof of principle, researchers at the California Institute of Technology have demonstrated that it is possible to program the pathways by which DNA strands self-assemble and disassemble, and hence to control the dynamic function of the molecules as they traverse these pathways.
Spinal cord damage blocks the routes that the brain uses to send messages to the nerve cells that control walking. Until now, doctors believed that the only way for injured patients to walk again was to re-grow the long nerve highways that link the brain and base of the spinal cord. For the first time, a UCLA study shows that the central nervous system can reorganize itself and follow new pathways to restore the cellular communication required for movement.
New research at the University of Chicago finds evidence for a clever way that people manage to alleviate the pain of loneliness: They create people in their surroundings to keep them company.
“Biological reproduction is not a very efficient way to alleviate one’s loneliness, but you can make up people when you’re motivated to do so,” said Nicholas Epley, Assistant Professor of Behavioral Science at the University of Chicago’s Graduate School of Business. “When people lack a sense of connection with other people, they are more likely to see their pets, gadgets or gods as human-like.”
Movie characters from the Terminator to the Bionic Woman use bionic eyes to zoom in on far-off scenes, have useful facts pop into their field of view, or create virtual crosshairs. Off the screen, virtual displays have been proposed for more practical purposes – visual aids to help vision-impaired people, holographic driving control panels and even as a way to surf the Web on the go.
The device to make this happen may be familiar. Engineers at the University of Washington have for the first time used manufacturing techniques at microscopic scales to combine a flexible, biologically safe contact lens with an imprinted electronic circuit and lights.
University of Pennsylvania engineers and physicians have developed a carbon nanopipette thousands of times thinner than a human hair that measures electric current and delivers fluids into cells. Researchers developed this tiny carbon-based tool to probe cells with minimal intrusion and inject fluids without damaging or inhibiting cell growth.
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